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Interaction Report

Major Interaction: Ibuprofen + Warfarin

Concurrent use significantly increases the risk of gastrointestinal bleeding. NSAIDs inhibit platelet aggregation and may prolong prothrombin time. Recommendation: Consider alternative analgesic such as Acetaminophen if appropriate, and closely monitor INR if concurrent use is necessary.

Moderate Interaction: Lisinopril + Ibuprofen

NSAIDs may reduce the antihypertensive effect of ACE inhibitors like Lisinopril and increase the risk of renal function deterioration. Recommendation: Monitor blood pressure routinely and check renal function if therapy is prolonged.